A Heroin Addiction Severity-Associated Intronic Single Nucleotide Polymorphism Modulates Alternative Pre-mRNA Splicing of the μ Opioid Receptor Gene OPRM1 via hnRNPH Interactions

Single nucleotide polymorphisms (SNPs) in the OPRM1 gene have been associated with vulnerability to opioid dependence. The current study identifies an association of an intronic SNP (rs9479757) with the severity of heroin addiction among Han-Chinese male heroin addicts. Individual SNP analysis and h...

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Autors principals: Xu, Jin, Lu, Zhigang, Xu, Mingming, Pan, Ling, Deng, Yi, Xie, Xiaohu, Liu, Huifen, Ding, Shixiong, Hurd, Yasmin L., Pasternak, Gavril W., Klein, Robert J., Cartegni, Luca, Zhou, Wenhua, Pan, Ying-Xian
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131016/
https://ncbi.nlm.nih.gov/pubmed/25122903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3986-13.2014
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