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Role of helicity of α-helical antimicrobial peptides to improve specificity
A major barrier to the use of antimicrobial peptides as antibiotics is the toxicity or ability to lyse eukaryotic cells. In this study, a 26-residue amphipathic α-helical antimicrobial peptide A12L/A20L (Ac-KWKSFLKTFKSLKKTVLHTLLKAISS-amide) was used as the framework to design a series of D- and L-di...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Higher Education Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4130925/ https://ncbi.nlm.nih.gov/pubmed/24805306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-014-0061-0 |
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