Role of helicity of α-helical antimicrobial peptides to improve specificity

A major barrier to the use of antimicrobial peptides as antibiotics is the toxicity or ability to lyse eukaryotic cells. In this study, a 26-residue amphipathic α-helical antimicrobial peptide A12L/A20L (Ac-KWKSFLKTFKSLKKTVLHTLLKAISS-amide) was used as the framework to design a series of D- and L-di...

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Bibliografiske detaljer
Main Authors: Huang, Yibing, He, Liyan, Li, Guirong, Zhai, Naicui, Jiang, Hongyu, Chen, Yuxin
Format: Artigo
Sprog:Inglês
Udgivet: Higher Education Press 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130925/
https://ncbi.nlm.nih.gov/pubmed/24805306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-014-0061-0
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