Strategic targeting of the PI3K–NFκB axis in cisplatin-resistant NSCLC

Chemoresistance is a major therapeutic challenge to overcome in NSCLC, in order to improve the current survival rates of <15% at 5 years. We and others have shown increased PI3K signaling in NSCLC to be associated with a more aggressive disease, and a poorer prognosis. In this study, targeted inh...

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Detalhes bibliográficos
Main Authors: Heavey, Susan, Godwin, Peter, Baird, Anne-Marie, Barr, Martin P, Umezawa, Kazuo, Cuffe, Sinéad, Finn, Stephen P, O’Byrne, Kenneth J, Gately, Kathy
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130730/
https://ncbi.nlm.nih.gov/pubmed/25025901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29841
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