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Chemoenzymatic Synthesis of Bifunctional Polyubiquitin Substrates for Monitoring Ubiquitin Chain Remodeling

Covalent attachment of ubiquitin to target proteins is one of the most pervasive post-translational modifications in eukaryotes. Target proteins are often modified with polymeric ubiquitin chains of defined lengths and linkages that may further undergo dynamic changes in composition in response to c...

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Detalhes bibliográficos
Main Authors: Trang, Vivian H., Rodgers, Margaret L., Boyle, Kevin J., Hoskins, Aaron A., Strieter, Eric R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130216/
https://ncbi.nlm.nih.gov/pubmed/24961813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402059
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