Complexin inhibits spontaneous release and synchronizes Ca(2+)-triggered synaptic vesicle fusion by distinct mechanisms

Previously we showed that fast Ca(2+)-triggered vesicle fusion with reconstituted neuronal SNAREs and synaptotagmin-1 begins from an initial hemifusion-free membrane point contact, rather than a hemifusion diaphragm, using a single vesicle–vesicle lipid/content mixing assay (Diao et al., 2012). When...

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Autors principals: Lai, Ying, Diao, Jiajie, Cipriano, Daniel J, Zhang, Yunxiang, Pfuetzner, Richard A, Padolina, Mark S, Brunger, Axel T
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2014
Matèries:
Biophysics and Structural Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130161/
https://ncbi.nlm.nih.gov/pubmed/25122624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03756
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