Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle–vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of membrane states upon Ca(2+)-injection at 250–500...

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Hauptverfasser: Diao, Jiajie, Grob, Patricia, Cipriano, Daniel J, Kyoung, Minjoung, Zhang, Yunxiang, Shah, Sachi, Nguyen, Amie, Padolina, Mark, Srivastava, Ankita, Vrljic, Marija, Shah, Ankita, Nogales, Eva, Chu, Steven, Brunger, Axel T
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2012
Schlagworte:
Biophysics and Structural Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514886/
https://ncbi.nlm.nih.gov/pubmed/23240085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00109
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