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A human stem cell model of early Alzheimer’s disease pathology in Down syndrome

Human cellular models of Alzheimer’s disease (AD) pathogenesis would enable the investigation of candidate pathogenic mechanisms in AD and the testing and developing of new therapeutic strategies. We report the development of AD pathologies in cortical neurons generated from human induced pluripoten...

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Main Authors: Shi, Yichen, Kirwan, Peter, Smith, James, MacLean, Glenn, Orkin, Stuart H., Livesey, Frederick J.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4129935/
https://ncbi.nlm.nih.gov/pubmed/22344463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003771
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