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A human stem cell model of early Alzheimer’s disease pathology in Down syndrome

Human cellular models of Alzheimer’s disease (AD) pathogenesis would enable the investigation of candidate pathogenic mechanisms in AD and the testing and developing of new therapeutic strategies. We report the development of AD pathologies in cortical neurons generated from human induced pluripoten...

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Autors principals: Shi, Yichen, Kirwan, Peter, Smith, James, MacLean, Glenn, Orkin, Stuart H., Livesey, Frederick J.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4129935/
https://ncbi.nlm.nih.gov/pubmed/22344463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003771
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