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An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo

Inhibitors of isoprenylcysteine carboxylmethyltransferase (Icmt) are promising anti-cancer agents, as modification by Icmt is an essential component of the protein prenylation pathway for a group of proteins that includes Ras GTPases. Cysmethynil, a prototypical indole-based inhibitor of Icmt, effec...

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Main Authors: Lau, Hiu Yeung, Ramanujulu, Pondy M, Guo, Dianyan, Yang, Tianming, Wirawan, Melissa, Casey, Patrick J, Go, Mei-Lin, Wang, Mei
פורמט: Artigo
שפה:Inglês
יצא לאור: Landes Bioscience 2014
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128870/
https://ncbi.nlm.nih.gov/pubmed/24971579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29692
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