Inhibin Alpha-Subunit (INHA) Expression in Adrenocortical Cancer Is Linked to Genetic and Epigenetic INHA Promoter Variation

Adrenocortical carcinoma (ACC) is a rare, but highly malignant tumor of unknown origin. Inhibin α-subunit (Inha) knockout mice develop ACCs following gonadectomy. In man, INHA expression varies widely within ACC tissues and its circulating peptide inhibin pro-αC has been described as a novel tumor m...

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Autores principales: Hofland, Johannes, Steenbergen, Jacobie, Voorsluijs, Jacoba M., Verbiest, Michael M. P. J., de Krijger, Ronald R., Hofland, Leo J., de Herder, Wouter W., Uitterlinden, Andre G., Feelders, Richard A., de Jong, Frank H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128726/
https://ncbi.nlm.nih.gov/pubmed/25111790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104944
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