Dipeptidyl Peptidase Inhibition Prevents Diastolic Dysfunction and Reduces Myocardial Fibrosis in a Mouse Model of Western Diet Induced Obesity

OBJECTIVE: Consumption of a high-fat/high-fructose Western diet (WD) is linked to rising obesity and heart disease, particularly diastolic dysfunction which characterizes early obesity/metabolic cardiomyopathy. Mounting evidence supports a role for inflammation, oxidative stress and fibrosis in the...

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Huvudupphovsmän: Bostick, Brian, Habibi, Javad, Ma, Lixin, Aroor, Annayya, Rehmer, Nathan, Hayden, Melvin R., Sowers, James R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128682/
https://ncbi.nlm.nih.gov/pubmed/24933400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2014.04.002
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