Co-targeting stress-activated Hsp27 and autophagy as a combinatorial strategy to amplify endoplasmic reticular stress in prostate cancer

Heat shock protein-27 (Hsp27) is a stress-activated multifunctional chaperone that inhibits treatment-induced apoptosis and causes treatment resistance in prostate and other cancers. We previously showed that targeted suppression of Hsp27 sensitizes cancer cells to hormone and chemotherapy. However,...

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Bibliographic Details
Main Authors: Kumano, Masafumi, Furukawa, Junya, Shiota, Masaki, Zardan, Anousheh, Zhang, Fan, Beraldi, Eliana, Wiedmann, Romina M., Fazli, Ladan, Zoubeidi, Amina, Gleave, Martin E.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128402/
https://ncbi.nlm.nih.gov/pubmed/22675041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0072
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