Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival

We define stress-induced adaptive survival pathways linking autophagy with the molecular chaperone clusterin (CLU) that function to promote anticancer treatment resistance. During treatment stress, CLU co-localizes with LC3 via an LIR-binding sequence within autophagosome membranes, functioning to f...

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Vydáno v:Nat Commun
Hlavní autoři: Zhang, Fan, Kumano, Masafumi, Beraldi, Eliana, Fazli, Ladan, Du, Caigan, Moore, Susan, Sorensen, Poul, Zoubeidi, Amina, Gleave, Martin E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4275590/
https://ncbi.nlm.nih.gov/pubmed/25503391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6775
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