Anti-apoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3(+) regulatory T cells

Foxp3(+) regulatory T (T(reg)) cells are a crucial immunosuppressive population of CD4(+) T cells, yet the homeostatic processes and survival programs that maintain the T(reg) cell pool are poorly understood. Here we report that peripheral T(reg) cells markedly alter their proliferative and apoptoti...

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Detalhes bibliográficos
Main Authors: Pierson, Wim, Cauwe, Bénédicte, Policheni, Antonia, Schlenner, Susan M., Franckaert, Dean, Berges, Julien, Humblet-Baron, Stephanie, Schonefeldt, Susann, Herold, Marco J., Hildeman, David, Strasser, Andreas, Bouillet, Philippe, Lu, Li-Fan, Matthys, Patrick, Freitas, Antonio A., Luther, Rita J., Weaver, Casey T., Dooley, James, Gray, Daniel H. D., Liston, Adrian
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128388/
https://ncbi.nlm.nih.gov/pubmed/23852275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2649
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