Clonal Progression during the T Cell-Dependent B Cell Antibody Response Depends on the Immunoglobulin D(H) Gene Segment Repertoire

The diversity of the third complementarity determining region of the IgH chain is constrained by natural selection of immunoglobulin diversity (D(H)) sequence. To test the functional significance of this constraint in the context of thymus-dependent (TD) immune responses, we immunized BALB/c mice wi...

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Main Authors: Trad, Ahmad, Tanasa, Radu Iulian, Lange, Hans, Zemlin, Michael, Schroeder, Harry W., Lemke, Hilmar
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2014
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128299/
https://ncbi.nlm.nih.gov/pubmed/25157256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00385
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