Crystal Structures of Ricin Toxin’s Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-neutralizing Single Chain Antibodies

Ricin is a Select Agent Toxin and a member of the RNA N-glycosidase family of medically important plant and bacterial ribosome-inactivating proteins (RIPs). In this study, we determined x-ray crystal structures of the enzymatic subunit of ricin (RTA) in complex with the antigen binding domains (VHH)...

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Autori principali: Rudolph, Michael J., Vance, David J., Cheung, Jonah, Franklin, Matthew C., Burshteyn, Fiana, Cassidy, Michael S., Gary, Ebony N., Herrera, Cristina, Shoemaker, Charles B., Mantis, Nicholas J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128236/
https://ncbi.nlm.nih.gov/pubmed/24907552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.05.026
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