Regulatory effects of SKAR in interferon α signaling and its role in the generation of type I IFN responses

We provide evidence that S6 kinase 1 (S6K1) Aly/REF-like target (SKAR) is engaged in IFN-α signaling and plays a key role in the generation of IFN responses. Our data demonstrate that IFN-α induces phosphorylation of SKAR, which is mediated by either the p90 ribosomal protein S6 kinase (RSK) or p70...

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Bibliografiske detaljer
Main Authors: Kroczynska, Barbara, Mehrotra, Swarna, Majchrzak-Kita, Beata, Arslan, Ahmet Dirim, Altman, Jessica K., Stein, Brady L., McMahon, Brandon, Kozlowski, Piotr, Kahle, Philipp J., Eklund, Elizabeth A., Fish, Eleanor N., Platanias, Leonidas C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128135/
https://ncbi.nlm.nih.gov/pubmed/25049393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405250111
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