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Side-chain conformation at the selectivity filter shapes the permeation free-energy landscape of an ion channel
On the basis of single-channel currents recorded from the muscle nicotinic acetylcholine receptor (AChR), we have recently hypothesized that the conformation adopted by the glutamate side chains at the first turn of the pore-lining α-helices is a key determinant of the rate of ion permeation. In thi...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4128128/ https://ncbi.nlm.nih.gov/pubmed/25049389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408950111 |
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