Molecular forms of HMGB1 and Keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

BACKGROUND & AIMS: Full length keratin-18 (FL-K18) and High Mobility Group Box-1 (HMGB1) represent circulating indicators of necrosis during acetaminophen (APAP) hepatotoxicity in vivo. In addition, the caspase-cleaved fragment of K18 (cK18) and hyper-acetylated HMGB1 represent serum indicators...

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Main Authors: Antoine, Daniel J, Jenkins, Rosalind E, Dear, James W, Williams, Dominic P, McGill, Mitchell R, Sharpe, Matthew R, Craig, Darren G, Simpson, Kenneth J, Jaeschke, Hartmut, Park, B. Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4127883/
https://ncbi.nlm.nih.gov/pubmed/22266604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2011.12.019
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