Exposure time independent summary statistics for assessment of drug dependent cell line growth inhibition

BACKGROUND: In vitro generated dose-response curves of human cancer cell lines are widely used to develop new therapeutics. The curves are summarised by simplified statistics that ignore the conventionally used dose-response curves’ dependency on drug exposure time and growth kinetics. This may lead...

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Detalhes bibliográficos
Main Authors: Falgreen, Steffen, Laursen, Maria Bach, Bødker, Julie Støve, Kjeldsen, Malene Krag, Schmitz, Alexander, Nyegaard, Mette, Johnsen, Hans Erik, Dybkær, Karen, Bøgsted, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4127655/
https://ncbi.nlm.nih.gov/pubmed/24902483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-15-168
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