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Impact of CYP2D*6 in the adjuvant treatment of breast cancer patients with tamoxifen
Biotransformation of tamoxifen to the potent antiestrogen endoxifen is performed by cytochrome P450 (CYP) enzymes, in particular the CYP2D6 isoform. CYP2D6*4 is one of the most frequent alleles associated with loss of enzymatic activity. The incidence of CYP2D6*4 among Caucasians is estimated up to...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Baishideng Publishing Group Inc
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4127608/ https://ncbi.nlm.nih.gov/pubmed/25114852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5306/wjco.v5.i3.374 |
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