The impact of CYP2D6-predicted phenotype on tamoxifen treatment outcome in patients with metastatic breast cancer

BACKGROUND: Cytochrome P450 2D6 (CYP2D6) has a crucial role in the metabolic conversion of tamoxifen into the active metabolite endoxifen. In this cohort study, the effect of CYP2D6-predicted phenotype, defined as the combined effect of CYP2D6 genetic variation and concomitant use of CYP2D6-inhibiti...

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Detalhes bibliográficos
Main Authors: Lammers, L A, Mathijssen, R H J, van Gelder, T, Bijl, M J, de Graan, A-J M, Seynaeve, C, van Fessem, M A, Berns, E M, Vulto, A G, van Schaik, R H N
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966615/
https://ncbi.nlm.nih.gov/pubmed/20700120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605800
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