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New Insights and Challenges in Mismatch Repair: Getting Over the Chromatin Hurdle
DNA mismatch repair (MMR) maintains genome stability primarily by repairing DNA replication-associated mispairs. Because loss of MMR function increases the mutation frequency genome-wide, defects in this pathway predispose affected individuals to cancer. The genes encoding essential eukaryotic MMR a...
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| Formato: | Artigo |
| Idioma: | Inglês |
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2014
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4127414/ https://ncbi.nlm.nih.gov/pubmed/24767944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.03.027 |
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