A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.

We have identified an antigen recognized on a human melanoma by autologous cytolytic T lymphocytes. It is encoded by a gene that is expressed in many normal tissues. Remarkably, the sequence coding for the antigenic peptide is located across an exon-intron junction. A point mutation is present in th...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Coulie, P G, Lehmann, F, Lethé, B, Herman, J, Lurquin, C, Andrawiss, M, Boon, T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41269/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7644523/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.17.7976
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