A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.

We have identified an antigen recognized on a human melanoma by autologous cytolytic T lymphocytes. It is encoded by a gene that is expressed in many normal tissues. Remarkably, the sequence coding for the antigenic peptide is located across an exon-intron junction. A point mutation is present in th...

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Bibliographic Details
Main Authors: Coulie, P G, Lehmann, F, Lethé, B, Herman, J, Lurquin, C, Andrawiss, M, Boon, T
Format: Artigo
Language:Inglês
Published: 1995
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC41269/
https://ncbi.nlm.nih.gov/pubmed/7644523
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