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Calcium Current Inactivation Rather than Pool Depletion Explains Reduced Exocytotic Rate with Prolonged Stimulation in Insulin-Secreting INS-1 832/13 Cells
Impairment in beta-cell exocytosis is associated with reduced insulin secretion and diabetes. Here we aimed to investigate the dynamics of Ca(2+)-dependent insulin exocytosis with respect to pool depletion and Ca(2+)-current inactivation. We studied exocytosis, measured as increase in membrane capac...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4126658/ https://ncbi.nlm.nih.gov/pubmed/25105407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103874 |
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