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Newcomer insulin secretory granules as a highly calcium-sensitive pool

Insulin secretion is biphasic in response to a step in glucose stimulation. Recent experiments suggest that 2 different mechanisms operate during the 2 phases, with transient first-phase secretion due to exocytosis of docked granules but the second sustained phase due largely to newcomer granules. A...

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Autores principales: Pedersen, Morten Gram, Sherman, Arthur
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678592/
https://ncbi.nlm.nih.gov/pubmed/19372374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901202106
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