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FISH comets show that the salvage enzyme TK1 contributes to gene-specific DNA repair
Thymidine kinase 1 (TK1) is a salvage enzyme that phosphorylates thymidine, imported from surrounding fluids, to create dTMP, which is further phosphorylated to the DNA precursor dTTP. TK1 deficiency has for a long time been known to cause increased cellular sensitivity to DNA damage. We have examin...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4126492/ https://ncbi.nlm.nih.gov/pubmed/25152750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2014.00233 |
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