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Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS

Neuroinflammation is a prominent pathological feature in the spinal cords of patients with amyotrophic lateral sclerosis (ALS), as well as in transgenic mouse models of inherited ALS, and is characterized by activated microglia. Earlier studies showed that activated microglia play important roles in...

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Autori principali: Liao, Bing, Zhao, Weihua, Beers, David R., Henkel, Jenny S., Appel, Stanley H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126417/
https://ncbi.nlm.nih.gov/pubmed/22735487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2012.06.011
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