Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor

In adults with sickle cell disease (SCD), markers of iron burden are associated with excessive production of the angiogenic protein placenta growth factor (PlGF) and high estimated pulmonary artery pressure. Enforced PlGF expression in mice stimulates production of the potent vasoconstrictor endothe...

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Hlavní autoři: Wang, Xunde, Mendelsohn, Laurel, Rogers, Heather, Leitman, Susan, Raghavachari, Nalini, Yang, Yanqin, Yau, Yu Ying, Tallack, Michael, Perkins, Andrew, Taylor, James G., Noguchi, Constance Tom, Kato, Gregory J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2014
Témata:
Red Cells, Iron, and Erythropoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126333/
https://ncbi.nlm.nih.gov/pubmed/24916507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-11-539718
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