Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor

In adults with sickle cell disease (SCD), markers of iron burden are associated with excessive production of the angiogenic protein placenta growth factor (PlGF) and high estimated pulmonary artery pressure. Enforced PlGF expression in mice stimulates production of the potent vasoconstrictor endothe...

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Autores principales: Wang, Xunde, Mendelsohn, Laurel, Rogers, Heather, Leitman, Susan, Raghavachari, Nalini, Yang, Yanqin, Yau, Yu Ying, Tallack, Michael, Perkins, Andrew, Taylor, James G., Noguchi, Constance Tom, Kato, Gregory J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2014
Materias:
Red Cells, Iron, and Erythropoiesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126333/
https://ncbi.nlm.nih.gov/pubmed/24916507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-11-539718
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