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Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor
In adults with sickle cell disease (SCD), markers of iron burden are associated with excessive production of the angiogenic protein placenta growth factor (PlGF) and high estimated pulmonary artery pressure. Enforced PlGF expression in mice stimulates production of the potent vasoconstrictor endothe...
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| Autores principales: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society of Hematology
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4126333/ https://ncbi.nlm.nih.gov/pubmed/24916507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-11-539718 |
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