Single Molecule Investigation of Ag(+) Interactions with Single Cytosine-, Methylcytosine- and Hydroxymethylcytosine-Cytosine Mismatches in a Nanopore

Both cytosine-Ag-cytosine interactions and cytosine modifications in a DNA duplex have attracted great interest for research. Cytosine (C) modifications such as methylcytosine (mC) and hydroxymethylcytosine (hmC) are associated with tumorigenesis. However, a method for directly discriminating C, mC...

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Bibliographic Details
Main Authors: Wang, Yong, Luan, Bin-Quan, Yang, Zhiyu, Zhang, Xinyue, Ritzo, Brandon, Gates, Kent, Gu, Li-Qun
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126007/
https://ncbi.nlm.nih.gov/pubmed/25103463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05883
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