The small molecule indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity

OBJECTIVES: Activation of the Wnt/β-catenin signaling pathway inhibits adipogenesis by maintaining preadipocytes in an undifferentiated state. We investigated the effect of indirubin-3′-oxime (I3O), which was screened as an activator of the Wnt/β-catenin signaling, on inhibiting the preadipocyte dif...

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Autors principals: Choi, O M, Cho, Y-H, Choi, S, Lee, S-H, Seo, S H, Kim, H-Y, Han, G, Min, D S, Park, T, Choi, K Y
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125748/
https://ncbi.nlm.nih.gov/pubmed/24232498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ijo.2013.209
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