Phosphorylation Dependence and Stoichiometry of the Complex Formed by Tyrosine Hydroxylase and 14-3-3γ

Phosphorylated tyrosine hydroxylase (TH) can form complexes with 14-3-3 proteins, resulting in enzyme activation and stabilization. Although TH was among the first binding partners identified for these ubiquitous regulatory proteins, the binding stoichiometry and the activation mechanism remain unkn...

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Autores principales: Kleppe, Rune, Rosati, Sara, Jorge-Finnigan, Ana, Alvira, Sara, Ghorbani, Sadaf, Haavik, Jan, Valpuesta, José María, Heck, Albert J. R., Martinez, Aurora
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2014
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125734/
https://ncbi.nlm.nih.gov/pubmed/24947669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M113.035709
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