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Discovering novel anti-HCV compounds with inhibitory activities toward HCV NS3/4A protease
AIM: To discover novel hepatitis C virus (HCV) inhibitors and elucidate the mechanism of action of the active compounds. METHODS: HCV subgenomic replicon-based luciferase reporter cell line was used to screen 1200 synthetic compounds with novel structures. Huh7.5.1 cell line stably transfected with...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4125721/ https://ncbi.nlm.nih.gov/pubmed/25066323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.55 |
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