Discovering novel anti-HCV compounds with inhibitory activities toward HCV NS3/4A protease

AIM: To discover novel hepatitis C virus (HCV) inhibitors and elucidate the mechanism of action of the active compounds. METHODS: HCV subgenomic replicon-based luciferase reporter cell line was used to screen 1200 synthetic compounds with novel structures. Huh7.5.1 cell line stably transfected with...

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Autores principales: Yu, Ye, Jing, Jing-feng, Tong, Xian-kun, He, Pei-lan, Li, Yuan-chao, Hu, You-hong, Tang, Wei, Zuo, Jian-ping
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125721/
https://ncbi.nlm.nih.gov/pubmed/25066323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.55
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