Discovery of novel aromatase inhibitors using a homogeneous time-resolved fluorescence assay

AIM: Aromatase is an important target for drugs to treat hormone-dependent diseases, including breast cancer. The aim of this study was to develop a homogeneous time-resolved fluorescence (HTRF) aromatase assay suitable for high-throughput screening (HTS). METHODS: A 384-well aromatase HTRF assay wa...

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Detalhes bibliográficos
Main Authors: Ji, Jin-zi, Lao, Ke-jing, Hu, Jie, Pang, Tao, Jiang, Zhen-zhou, Yuan, Hao-liang, Miao, Jing-shan, Chen, Xin, Ning, Shan-shan, Xiang, Hua, Guo, Yu-meng, Yan, Ming, Zhang, Lu-yong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125720/
https://ncbi.nlm.nih.gov/pubmed/25047514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.53
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