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MicroRNA-150 regulates the cytotoxicity of natural killers by targeting perforin-1
BACKGROUND: Perforin-1 is the predominant cytolytic protein secreted by natural killer cells. For a rapid immune response, resting NK cells contain high Prf1 mRNA concentrations while exhibiting minimal cytotoxicity due to a blockage of Prf1 protein synthesis, implying that an unknown post-transcrip...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4125537/ https://ncbi.nlm.nih.gov/pubmed/24698324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.02.018 |
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