Human microRNA-27a* targets Prf1 and GzmB expression to regulate NK-cell cytotoxicity

Perforin (Prf1) and granzyme B (GzmB) are essential effector molecules for natural killer (NK)–cell cytotoxicity, but how Prf1 and GzmB expression is regulated during arming of NK cells is poorly defined. We show that human microRNA (miR)–27a* is a negative regulator of NK-cell cytotoxicity by silen...

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Detaylı Bibliyografya
Asıl Yazarlar: Kim, Tae-Don, Lee, Su Ui, Yun, Sohyun, Sun, Hu-Nan, Lee, Suk Hyung, Kim, Jae Wha, Kim, Hwan Mook, Park, Song-Kyu, Lee, Chang Woo, Yoon, Suk Ran, Greenberg, Philip D., Choi, Inpyo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2011
Konular:
Immunobiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217350/
https://ncbi.nlm.nih.gov/pubmed/21960590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-347526
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