Human microRNA-27a* targets Prf1 and GzmB expression to regulate NK-cell cytotoxicity

Perforin (Prf1) and granzyme B (GzmB) are essential effector molecules for natural killer (NK)–cell cytotoxicity, but how Prf1 and GzmB expression is regulated during arming of NK cells is poorly defined. We show that human microRNA (miR)–27a* is a negative regulator of NK-cell cytotoxicity by silen...

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Detalhes bibliográficos
Main Authors: Kim, Tae-Don, Lee, Su Ui, Yun, Sohyun, Sun, Hu-Nan, Lee, Suk Hyung, Kim, Jae Wha, Kim, Hwan Mook, Park, Song-Kyu, Lee, Chang Woo, Yoon, Suk Ran, Greenberg, Philip D., Choi, Inpyo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217350/
https://ncbi.nlm.nih.gov/pubmed/21960590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-347526
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