DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells

Ku-dependent C-NHEJ (classic non-homologous end joining) is the primary DNA EJing (end joining) repair pathway in mammals. Recently, an additional EJing repair pathway (A-NHEJ; alternative-NHEJ) has been described. Currently, the mechanism of A-NHEJ is obscure although a dependency on LIGIII (DNA li...

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Bibliographic Details
Main Authors: Oh, Sehyun, Harvey, Adam, Zimbric, Jacob, Wang, Yongbao, Nguyen, Thanh, Jackson, Pauline J., Hendrickson, Eric A.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125535/
https://ncbi.nlm.nih.gov/pubmed/24837021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.04.015
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