Guanidino Groups Greatly Enhance the Action of Antimicrobial Peptidomimetics Against Bacterial Cytoplasmic Membranes

A promising class of potential new antibiotics are the antimicrobial peptides or their synthetic mimics. Herein we assess the effect of the type of cationic side chain (i.e., guanidino vs. amino groups) on the membrane perturbing mechanism of antimicrobial α-peptide–β-peptoid chimeras. Two separate...

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Bibliografiset tiedot
Päätekijät: Andreev, Konstantin, Bianchi, Christopher, Laursen, Jonas S., Citterio, Linda, Hein-Kristensen, Line, Gram, Lone, Kuzmenko, Ivan, Olsen, Christian A., Gidalevitz, David
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125507/
https://ncbi.nlm.nih.gov/pubmed/24878450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2014.05.022
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