Guanidino Groups Greatly Enhance the Action of Antimicrobial Peptidomimetics Against Bacterial Cytoplasmic Membranes

A promising class of potential new antibiotics are the antimicrobial peptides or their synthetic mimics. Herein we assess the effect of the type of cationic side chain (i.e., guanidino vs. amino groups) on the membrane perturbing mechanism of antimicrobial α-peptide–β-peptoid chimeras. Two separate...

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Main Authors: Andreev, Konstantin, Bianchi, Christopher, Laursen, Jonas S., Citterio, Linda, Hein-Kristensen, Line, Gram, Lone, Kuzmenko, Ivan, Olsen, Christian A., Gidalevitz, David
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125507/
https://ncbi.nlm.nih.gov/pubmed/24878450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2014.05.022
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