EGFR variant heterogeneity in glioblastoma resolved through single-nucleus sequencing

Glioblastomas with EGFR amplification represent approximately 50% of newly diagnosed cases and recent studies have revealed frequent coexistence of multiple EGFR aberrations within the same tumor with implications for mutation cooperation and treatment resistance. However, bulk tumor sequencing stud...

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Hoofdauteurs: Francis, Joshua M., Zhang, Cheng-Zhong, Maire, Cecile L., Jung, Joonil, Manzo, Veronica E., Adalsteinsson, Viktor A., Homer, Heather, Haidar, Sam, Blumenstiel, Brendan, Pedamallu, Chandra Sekhar, Ligon, Azra H., Love, J. Christopher, Meyerson, Matthew, Ligon, Keith L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125473/
https://ncbi.nlm.nih.gov/pubmed/24893890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0879
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