EGFR variant heterogeneity in glioblastoma resolved through single-nucleus sequencing

Glioblastomas with EGFR amplification represent approximately 50% of newly diagnosed cases and recent studies have revealed frequent coexistence of multiple EGFR aberrations within the same tumor with implications for mutation cooperation and treatment resistance. However, bulk tumor sequencing stud...

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Detalhes bibliográficos
Main Authors: Francis, Joshua M., Zhang, Cheng-Zhong, Maire, Cecile L., Jung, Joonil, Manzo, Veronica E., Adalsteinsson, Viktor A., Homer, Heather, Haidar, Sam, Blumenstiel, Brendan, Pedamallu, Chandra Sekhar, Ligon, Azra H., Love, J. Christopher, Meyerson, Matthew, Ligon, Keith L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125473/
https://ncbi.nlm.nih.gov/pubmed/24893890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0879
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