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Leptin attenuates BACE1 expression and Amyloid-β genesis via the activation of SIRT1 signaling pathway
The aspartyl protease β-site AβPP-cleaving enzyme 1 (BACE1) catalyzes the rate-limiting step in Aβ production, a peptide at the nexus of neurodegenerative cascades in Alzheimer Disease (AD). The adipocytokine leptin has been demonstrated to reduce Aβ production and decrease BACE1 activity and expres...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4125440/ https://ncbi.nlm.nih.gov/pubmed/24874077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2014.05.015 |
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