A Stereoelectronic Basis for the Kinetic Resolution of N-Heterocycles with Chiral Acylating Reagents

The kinetic resolution of N-heterocycles with chiral acylating agents reveals a previously unrecognized stereoelectronic effect in amine acylation. Combined with a new achiral hydroxamate, this effect makes possible the resolution of various N-heterocycles using easily prepared reagents. A transitio...

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Hauptverfasser: Hsieh, Sheng-Ying, Wanner, Benedikt, Wheeler, Philip, Beauchemin, André M., Rovis, Tomislav, Bode, Jeffrey W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125202/
https://ncbi.nlm.nih.gov/pubmed/24839065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201402818
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