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Mouse models address key concerns regarding autophagy inhibition in cancer therapy

With multiple clinical trials underway targeting autophagy against cancer, Yang et al. (1) and Karsli-Uzunbas et al. (2) address important concerns regarding autophagy inhibition in cancer patients using genetically engineered mouse models (GEMMs) that more accurately represent the tumor biology fou...

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Detalhes bibliográficos
Main Authors: Amaravadi, Ravi, Debnath, Jayanta
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4124512/
https://ncbi.nlm.nih.gov/pubmed/25092744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0618
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