2′-(2-bromohexadecanoyl)-paclitaxel conjugate nanoparticles for the treatment of non-small cell lung cancer in an orthotopic xenograft mouse model

A nanoparticle (NP) formulation with 2′-(2-bromohexadecanoyl)-paclitaxel (Br-16-PX) conjugate was developed in these studies for the treatment of non-small cell lung cancer (NSCLC). The lipophilic paclitaxel conjugate Br-C16-PX was synthesized and incorporated into lipid NPs where the 16-carbon chai...

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Detalhes bibliográficos
Main Authors: Peng, Lei, Schorzman, Allison N, Ma, Ping, Madden, Andrew J, Zamboni, William C, Benhabbour, Soumya Rahima, Mumper, Russell J
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4124067/
https://ncbi.nlm.nih.gov/pubmed/25114529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S66040
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