Restoring ciliary function to differentiated Primary Ciliary Dyskinesia cells with a lentiviral vector

Primary ciliary dyskinesia is a genetically heterogeneous autosomal recessive disease in which mutations disrupt ciliary function, leading to impaired mucociliary clearance and life-long lung disease. Mouse tracheal cells with a targeted deletion in the axonemal dynein intermediated chain gene Dnaic...

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Main Authors: Ostrowski, Lawrence E, Yin, Weining, Patel, Manij, Sechelski, John, Rogers, Troy, Burns, Kimberlie, Grubb, Barbara R, Olsen, John C
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4124007/
https://ncbi.nlm.nih.gov/pubmed/24451115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2013.79
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