Cryo-electron tomography reveals ciliary defects underlying human RSPH1 primary ciliary dyskinesia

Cilia play essential roles in normal human development and health; cilia dysfunction results in diseases such as primary ciliary dyskinesia (PCD). Despite their importance, the native structure of human cilia is unknown, and structural defects in the cilia of patients are often undetectable or remai...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Lin, Jianfeng, Yin, Weining, Smith, Maria C., Song, Kangkang, Leigh, Margaret W., Zariwala, Maimoona A., Knowles, Michael R., Ostrowski, Lawrence E., Nicastro, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267722/
https://ncbi.nlm.nih.gov/pubmed/25473808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6727
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