Upregulation of Immunoproteasome Subunits in Myositis Indicates Active Inflammation with Involvement of Antigen Presenting Cells, CD8 T-Cells and IFNγ

OBJECTIVE: In idiopathic inflammatory myopathies (IIM) infiltration of immune cells into muscle and upregulation of MHC-I expression implies increased antigen presentation and involvement of the proteasome system. To decipher the role of immunoproteasomes in myositis, we investigated individual cell...

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Main Authors: Ghannam, Khetam, Martinez-Gamboa, Lorena, Spengler, Lydia, Krause, Sabine, Smiljanovic, Biljana, Bonin, Marc, Bhattarai, Salyan, Grützkau, Andreas, Burmester, Gerd-R., Häupl, Thomas, Feist, Eugen
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123911/
https://ncbi.nlm.nih.gov/pubmed/25098831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104048
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