Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway

The Bone Morphogenetic Protein antagonist Gremlin 2 (Grem2) is required for atrial differentiation and establishment of cardiac rhythm during embryonic development. A human Grem2 variant has been associated with familial atrial fibrillation, suggesting that abnormal Grem2 activity causes arrhythmias...

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Main Authors: Tanwar, Vineeta, Bylund, Jeffery B., Hu, Jianyong, Yan, Jingbo, Walthall, Joel M., Mukherjee, Amrita, Heaton, William H., Wang, Wen-Der, Potet, Franck, Rai, Meena, Kupershmidt, Sabina, Knapik, Ela W., Hatzopoulos, Antonis K.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2014
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123739/
https://ncbi.nlm.nih.gov/pubmed/24648383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1703
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